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KMID : 0613820120220081092
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Journal of Life Science
2012 Volume.22 No. 8 p.1092 ~ p.1098
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Anti-wrinkle Compounds Isolated from the Seeds of Arctium lappa L.
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Hwang Ju-Young
Park Tae-Soon
Kim Dong-Hee
Hwang Eun-Young
Lee Jung-Noh
Lee Ji-Young
Lee Ghang-Tai
Lee Kun-Kook
Son Jun-Ho
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Abstract
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This study was carried out to discover the skin wrinkle reducing components in the seeds of Arctium lappa. The isolation of a methylene chloride-soluble fraction of 70% ethanol extract from the seeds of Arctium lappa using a procollagen type-1 synthesis and MMP-1 activity resulted in the isolation and identification of four lignin compounds: arctiin, arctigenin, matairesinol, and diarctigenin. All structures were confirmed via NMR and MS spectroscopic data. To determine cell viability and procollagen type-1 synthesis, human dermal fibroblasts were treated with 10-100 μM. As a result, none of the four compounds showed cytotoxicity up to 50 μM. We also investigated their procollagen type-1 synthesis and MMP-1 inhibition activity and found that arctiin had the highest activity in terms of both procollagen synthesis and MMP-1 inhibition among all four compounds. Putting all the data together, we suggest that arctiin be used in cosmetics as an anti-wrinkle material.
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KEYWORD
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Arctium lappa, arctiin, procollagen type-1 synthesis, matrix metalloproteinase (MMP) inhibition activity
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